Summary of HSD11B1

The gene codes for a protein, hydroxysteroid 11-beta dehydrogenase 1. Mutations cause cortisone reductase deficiency [R].

The Function of HSD11B1

Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol.

Protein names

Recommended name:

Corticosteroid 11-beta-dehydrogenase isozyme 1

Short name:


Alternative name(s):

11-beta-hydroxysteroid dehydrogenase 1
Short chain dehydrogenase/reductase family 26C member 1

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Top Gene-Substance Interactions

HSD11B1 Interacts with These Diseases

Substances That Increase HSD11B1

Substances That Decrease HSD11B1

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity