Summary of HNF4A

HNF4-alpha plays a role in the development of the liver, kidney, and intestines. HNF4A is required for the PXR and CAR activation of CYP3A4, which is needed to metabolize a bunch of drugs and toxins.

HNF4-A may also have direct effects on various genes associated with amine synthesis, have an influence on homeostasis, and may lower insulin resistance. 

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Protein names

Recommended name:

Hepatocyte nuclear factor 4-alpha

Short name:


Alternative name(s):

Nuclear receptor subfamily 2 group A member 1
Transcription factor 14
Transcription factor HNF-4

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Top Gene-Substance Interactions

HNF4A Interacts with These Diseases


Substances That Increase HNF4A

Substances That Decrease HNF4A

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity