Summary of HNF1A

This gene encodes a protein that is a transcription factor required for the expression of several liver-specific genes. This gene is associated with diabetes (R).


The Function of HNF1A

Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.

Protein names

Recommended name:

Hepatocyte nuclear factor 1-alpha

Short name:

LFB1

Alternative name(s):

HNF-1-alpha
HNF-1A
Liver-specific transcription factor LF-B1
Transcription factor 1
TCF-1

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Top Gene-Substance Interactions

Substances That Increase HNF1A

Substances That Decrease HNF1A

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical