Summary of HMGCR

This gene encodes an enzyme that catalyzes the rate limiting step in cholesterol biosynthesis (R). 

The Function of HMGCR

Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

Protein names

Recommended name:

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Alternative name(s):

HMG-CoA reductase

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Top Gene-Substance Interactions

HMGCR Interacts with These Diseases

Substances That Increase HMGCR

Substances That Decrease HMGCR

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity