Summary of HIF1A

HIF1A encodes HIF which regulates responses to hypoxia by activating transcription of genes that cause the development of blood vessels, cell death, energy metabolism, etc. (R). 

Overexpression of HIF1A can cause cancer and tumor progression (R). 

The Function of HIF1A

Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.

Protein names

Recommended name:

Hypoxia-inducible factor 1-alpha

Alternative name(s):

ARNT-interacting protein
Basic-helix-loop-helix-PAS protein MOP1
Class E basic helix-loop-helix protein 78
Member of PAS protein 1
PAS domain-containing protein 8

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Top Gene-Substance Interactions

HIF1A Interacts with These Diseases


Substances That Increase HIF1A

Substances That Decrease HIF1A

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity