Summary of HFE

This gene encodes a protein that helps keep track of the amount of iron in the body. It is associated with anemia (R).


Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.

Protein names

Recommended name:

Hereditary hemochromatosis protein

Short name:


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Top Gene-Substance Interactions

HFE Interacts with These Diseases

Substances That Increase HFE

Substances That Decrease HFE

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity