Summary of HDAC4

This gene encodes a protein that helps regulate gene transcription and cell cycle progress. Mutations can cause developmental problems (R).

The Function of HDAC4

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

Protein names

Recommended name:

Histone deacetylase 4

Short name:


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Top Gene-Substance Interactions

HDAC4 Interacts with These Diseases

Substances That Increase HDAC4

Substances That Decrease HDAC4

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity