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H2AFX (H2A histone family member X)

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Summary of H2AFX

This gene encodes a protein that is needed for DNA formation (R).

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The Function of H2AFX

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

Protein names

Recommended name:

Histone H2AX

Alternative name(s):

H2a/x
Histone H2A.X

H2AFX SNPs

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  1. RS2509049 (H2AFX) ??

Top Gene-Substance Interactions

H2AFX Interacts with These Diseases

Disease Score

Substances That Increase H2AFX

Substances Interaction Organism Category

Substances That Decrease H2AFX

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • GATA-3
  • AP-1
  • c-Jun
  • YY1

Gene Pathways:

  • Gene Expression
  • Mus musculus biological processes
  • DNA Repair
  • Cellular responses to stress
  • Systemic lupus erythematosus
  • Chromatin organization
  • Signal Transduction
  • Disease

Developmental stage:

Synthesized in G1 as well as in S-phase.

Molecular Function:

  • Dna Binding
  • Damaged Dna Binding
  • Enzyme Binding
  • Histone Binding

Biological Processes:

  • Dna Damage Checkpoint
  • Double-Strand Break Repair Via Homologous Recombination
  • Double-Strand Break Repair
  • Double-Strand Break Repair Via Nonhomologous End Joining
  • Nucleosome Assembly
  • Chromatin Silencing
  • Cellular Response To Dna Damage Stimulus
  • Spermatogenesis
  • Response To Ionizing Radiation
  • Viral Process
  • Cerebral Cortex Development
  • Positive Regulation Of Dna Repair
  • Meiotic Cell Cycle
  • Cellular Response To Gamma Radiation
  • Cellular Senescence
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| EGK_06977| gammaH2ax| H2A histone family, member X| H2a/x| H2AX| H2A.X| H2AX histone| hist1h2ab| Hist5-2ax| histone 1, H2ab| histone 5 protein 2ax| histone H2A.x| histone H2AX| RGD1566119| h2afx

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