Summary of GRIN2A

This gene encodes a protein that works as a glutamate receptor. Theyare the predominant neurotransmitter receptors in the brain and are used in a variety of normal brain processes. Mutations can cause mental retardation and epilepsy (R).

The Function of GRIN2A

NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.

Protein names

Recommended name:

Glutamate receptor ionotropic, NMDA 2A

Short name:


Alternative name(s):

Glutamate [NMDA] receptor subunit epsilon-1
N-methyl D-aspartate receptor subtype 2A

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Top Gene-Substance Interactions

GRIN2A Interacts with These Diseases

Substances That Increase GRIN2A

Substances That Decrease GRIN2A

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity