This gene encodes a protein that works as a glutamate receptor. Theyare the predominant neurotransmitter receptors in the brain and are used in a variety of normal brain processes. Mutations can cause mental retardation and epilepsy (R).


NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.

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