Summary of GRIN1

The gene codes for a protein, glutamate ionotropic receptor NMDA type subunit 1. It plays a role in the plasticity of synapses [R].

The Function of GRIN1

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.

Protein names

Recommended name:

Glutamate receptor ionotropic, NMDA 1

Alternative name(s):

Glutamate [NMDA] receptor subunit zeta-1
N-methyl-D-aspartate receptor subunit NR1

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Top Gene-Substance Interactions

GRIN1 Interacts with These Diseases

Substances That Increase GRIN1

Substances That Decrease GRIN1

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity