The Function of GREB1
May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.
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Protein names
Recommended name:
Protein GREB1Alternative name(s):
Gene regulated in breast cancer 1 protein- RS13394619 (GREB1) ??
- RS1435547 (GREB1) ??
- RS73175262 (GREB1) ??
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Top Gene-Substance Interactions
GREB1 Interacts with These Diseases
| Disease | Score |
Substances That Increase GREB1
| Substances | Interaction | Organism | Category |
Substances That Decrease GREB1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in proliferating prostatic tissue and prostate cancer.
Induction:
Estrogen-responsive; regulated by estrogen receptors. Regulated by androgens. The regulatory region of the gene contains 3 estrogen-responsive elements.
*synonyms