Summary of GPX1

GPX1 encodes a member of the glutathione peroxidase family, which contains important antioxidant enzymes and helps detoxify hydrogen peroxide with glutathione, and thereby protect cells against oxidative damage (R). It protects the hemoglobin in red blood cells from oxidative breakdown.

H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of antioxidant balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes.

It is also a selenoprotein, requiring selenium to function.

Associated with risk for breast cancer (R). 

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Protein names

Recommended name:

Glutathione peroxidase 1

Alternative name(s):

Cellular glutathione peroxidase

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Top Gene-Substance Interactions

GPX1 Interacts with These Diseases


Substances That Increase GPX1

Substances That Decrease GPX1

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity