Summary of GPT

Also known as DPAGT1, it encodes an enzyme that catalyzes the first step in glycoprotein biosynthesis. Mutations can cause muscle weakness and developmental disorders (R).

The Function of GPT

Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles.

Protein names

Recommended name:

Alanine aminotransferase 1

Short name:


Alternative name(s):

Glutamate pyruvate transaminase 1
Glutamic--alanine transaminase 1
Glutamic--pyruvic transaminase 1

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Top Gene-Substance Interactions

GPT Interacts with These Diseases

Substances That Increase GPT

Substances That Decrease GPT

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity