Summary of GPT
Also known as DPAGT1, it encodes an enzyme that catalyzes the first step in glycoprotein biosynthesis. Mutations can cause muscle weakness and developmental disorders (R).
The Function of GPT
Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles.
Protein names
Recommended name:
Alanine aminotransferase 1Short name:
ALT1Alternative name(s):
Glutamate pyruvate transaminase 1GPT 1
Glutamic--alanine transaminase 1
Glutamic--pyruvic transaminase 1
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- RS1063739 (GPT) ??
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Top Gene-Substance Interactions
GPT Interacts with These Diseases
| Disease | Score |
Substances That Increase GPT
| Substances | Interaction | Organism | Category |
Substances That Decrease GPT
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression (R):
Tissue specificity:
Liver, kidney, heart, and skeletal muscles. Expressed at moderate levels in the adipose tissue.
Induction:
By glucocorticoids.
Molecular Function:
Biological Processes:
Drug Bank:
- L-Alanine
- Phenelzine