The Function of GOT1

Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.

Protein names

Recommended name:

Aspartate aminotransferase, cytoplasmic

Alternative name(s):

Cysteine aminotransferase, cytoplasmic
Cysteine transaminase, cytoplasmic
Glutamate oxaloacetate transaminase 1
Transaminase A

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Top Gene-Substance Interactions

GOT1 Interacts with These Diseases

Substances That Increase GOT1

Substances That Decrease GOT1

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity