Summary of GBP2

This gene encodes a protein that is a GTPase which hydrolyzes GTP (R).

The Function of GBP2

Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832). Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.

Protein names

Recommended name:

Guanylate-binding protein 2

Short name:


Alternative name(s):

GTP-binding protein 2
Guanine nucleotide-binding protein 2
Interferon-induced guanylate-binding protein 2

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Top Gene-Substance Interactions

GBP2 Interacts with These Diseases

Substances That Increase GBP2

Substances That Decrease GBP2

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity