Summary of GABBR2

This gene encodes a protein that regulatse the release of neurotransmitters and the activity of ion channels. It is associated with susceptibility to tobacco addiction (R). 

The Function of GABBR2

Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.

Protein names

Recommended name:

Gamma-aminobutyric acid type B receptor subunit 2

Alternative name(s):

GABA-B receptor 2
G-protein coupled receptor 51

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Top Gene-Substance Interactions

GABBR2 Interacts with These Diseases

Substances That Increase GABBR2

Substances That Decrease GABBR2

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity