Summary of FTO

FTO genes are implicated in obesity, but scientists aren't sure exactly how.  The advanced section goes through the details.


Function

Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine (PubMed:18775698, PubMed:20376003). Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:22002720, PubMed:26458103). Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation (PubMed:18775698, PubMed:20376003). In particular, it is involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (PubMed:26287746).

Protein names

Recommended name:

Alpha-ketoglutarate-dependent dioxygenase FTO

Alternative name(s):

Fat mass and obesity-associated protein

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Top Gene-Substance Interactions

FTO Interacts with These Diseases

Fixes

Substances That Increase FTO

Substances That Decrease FTO

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical