Summary of FPGS

This gene encodes a protein that helps with folate homeostasis and with the proliferation of cells (R).

The Function of FPGS

Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates.

Protein names

Recommended name:

Folylpolyglutamate synthase, mitochondrial

Short name:


Alternative name(s):

Folylpoly-gamma-glutamate synthetase
Tetrahydrofolylpolyglutamate synthase
Tetrahydrofolate synthase

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Top Gene-Substance Interactions

FPGS Interacts with These Diseases

Substances That Increase FPGS

Substances That Decrease FPGS

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity