The Function of FOS

Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.

Protein names

Recommended name:

Proto-oncogene c-Fos

Alternative name(s):

Cellular oncogene fos
G0/G1 switch regulatory protein 7

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Top Gene-Substance Interactions

FOS Interacts with These Diseases

Substances That Increase FOS

Substances That Decrease FOS

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical