Summary of FBN1

This gene encodes for a fibrillin protein. Processing generates two proteins including fibrillin 1 and asprosin. Fibrillin-1 provides structural support in connective tissue. Asprosin regulates glucose and maintains it at homeostasis [R].

The Function of FBN1

Asprosin: Hormone that targets the liver to increase plasma glucose levels. Secreted by white adipose tissue and circulates in the plasma. Acts in response to fasting and promotes blood glucose elevation by binding to the surface of hepathocytes. Promotes hepathocyte glucose release by activating the protein kinase A activity in the liver, resulting in rapid glucose release into the circulation.

Protein names

Recommended name:

Fibrillin-1 [Cleaved into: Asprosin]

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Top Gene-Substance Interactions

FBN1 Interacts with These Diseases

Substances That Increase FBN1

Substances That Decrease FBN1

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity