Summary of FAS

This gene encodes a protein that helps with cell signaling. Mutations can cause cancer (R).

The Function of FAS

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).

Protein names

Recommended name:

Tumor necrosis factor receptor superfamily member 6

Alternative name(s):

Apo-1 antigen
Apoptosis-mediating surface antigen FAS
FASLG receptor
CD antigen CD95

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Top Gene-Substance Interactions

FAS Interacts with These Diseases

Substances That Increase FAS

Substances That Decrease FAS

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity