Summary of ERCC2

The ERCC2 gene encodes a protein called XPD. This protein is a part of the TFIIH complex, which is involved in gene transcription and helps repair damaged DNA (R). 

The Function of ERCC2

ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.

Protein names

Recommended name:

TFIIH basal transcription factor complex helicase XPD subunit

Short name:


Alternative name(s):

Basic transcription factor 2 80 kDa subunit
BTF2 p80
DNA excision repair protein ERCC-2
DNA repair protein complementing XP-D cells
TFIIH basal transcription factor complex 80 kDa subunit
TFIIH 80 kDa subunit
Xeroderma pigmentosum group D-complementing protein

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Top Gene-Substance Interactions

ERCC2 Interacts with These Diseases

Substances That Increase ERCC2

Substances That Decrease ERCC2

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity