Summary of ERBB2

This gene encodes a protein that needs a coreceptor to bind ligands. It is associated with cancer (R).


Function

In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.

Protein names

Recommended name:

Receptor tyrosine-protein kinase erbB-2

Short name:

MLN 19

Alternative name(s):

Metastatic lymph node gene 19 protein
Proto-oncogene Neu
Proto-oncogene c-ErbB-2
Tyrosine kinase-type cell surface receptor HER2
p185erbB2
CD antigen CD340

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Top Gene-Substance Interactions

ERBB2 Interacts with These Diseases

Substances That Increase ERBB2

Substances That Decrease ERBB2

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical