The Function of ECHS1

Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate.

Protein names

Recommended name:

Enoyl-CoA hydratase, mitochondrial

Short name:


Alternative name(s):

Enoyl-CoA hydratase 1
Short-chain enoyl-CoA hydratase

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Top Gene-Substance Interactions

ECHS1 Interacts with These Diseases

Substances That Increase ECHS1

Substances That Decrease ECHS1

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity