The Function of DUSP1
Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.
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Protein names
Recommended name:
Dual specificity protein phosphatase 1Short name:
MKP-1Alternative name(s):
Dual specificity protein phosphatase hVH1Mitogen-activated protein kinase phosphatase 1
MAP kinase phosphatase 1
Protein-tyrosine phosphatase CL100
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- RS17658229 (DUSP1) ??
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Top Gene-Substance Interactions
DUSP1 Interacts with These Diseases
| Disease | Score |
Substances That Increase DUSP1
| Substances | Interaction | Organism | Category |
Substances That Decrease DUSP1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.
Gene Pathways:
Induction:
By oxidative stress and heat shock.
Molecular Function:
- Non-Membrane Spanning Protein Tyrosine Phosphatase Activity
- Protein Tyrosine/Threonine Phosphatase Activity
- Map Kinase Tyrosine/Serine/Threonine Phosphatase Activity
Biological Processes:
- Inactivation Of Mapk Activity
- Endoderm Formation
- Response To Oxidative Stress
- Response To Light Stimulus
- Response To Estradiol
- Response To Retinoic Acid
- Cellular Response To Hormone Stimulus
- Response To Testosterone
- Peptidyl-Tyrosine Dephosphorylation
- Intracellular Signal Transduction
- Peptidyl-Threonine Dephosphorylation
- Response To Hydrogen Peroxide
- Regulation Of Apoptotic Process
- Positive Regulation Of Apoptotic Process
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of Map Kinase Activity
- Negative Regulation Of Mapk Cascade
- Response To Glucocorticoid
- Negative Regulation Of Meiotic Cell Cycle
- Response To Camp
- Response To Calcium Ion
- Negative Regulation Of Erk1 And Erk2 Cascade
- Mitotic Cell Cycle Arrest
- Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
- Negative Regulation Of Dna Biosynthetic Process