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DUSP1 (Dual specificity phosphatase 1)

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The Function of DUSP1

Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.

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Protein names

Recommended name:

Dual specificity protein phosphatase 1

Short name:

MKP-1

Alternative name(s):

Dual specificity protein phosphatase hVH1
Mitogen-activated protein kinase phosphatase 1
MAP kinase phosphatase 1
Protein-tyrosine phosphatase CL100

DUSP1 SNPs

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  1. RS17658229 (DUSP1) ??

Top Gene-Substance Interactions

DUSP1 Interacts with These Diseases

Disease Score

Substances That Increase DUSP1

Substances Interaction Organism Category

Substances That Decrease DUSP1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • AP-1
  • c-Jun
  • E2F-1
  • c-Fos

Tissue specificity:

Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.

Gene Pathways:

  • MAPK signaling pathway

Induction:

By oxidative stress and heat shock.

Molecular Function:

  • Non-Membrane Spanning Protein Tyrosine Phosphatase Activity
  • Protein Tyrosine/Threonine Phosphatase Activity
  • Map Kinase Tyrosine/Serine/Threonine Phosphatase Activity

Biological Processes:

  • Inactivation Of Mapk Activity
  • Endoderm Formation
  • Response To Oxidative Stress
  • Response To Light Stimulus
  • Response To Estradiol
  • Response To Retinoic Acid
  • Cellular Response To Hormone Stimulus
  • Response To Testosterone
  • Peptidyl-Tyrosine Dephosphorylation
  • Intracellular Signal Transduction
  • Peptidyl-Threonine Dephosphorylation
  • Response To Hydrogen Peroxide
  • Regulation Of Apoptotic Process
  • Positive Regulation Of Apoptotic Process
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Map Kinase Activity
  • Negative Regulation Of Mapk Cascade
  • Response To Glucocorticoid
  • Negative Regulation Of Meiotic Cell Cycle
  • Response To Camp
  • Response To Calcium Ion
  • Negative Regulation Of Erk1 And Erk2 Cascade
  • Mitotic Cell Cycle Arrest
  • Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
  • Negative Regulation Of Dna Biosynthetic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 3CH134| 3CH134/CL100 PTPase| AS27_11899| AS28_10258| CB1_000672002| CL100| CL 100| D623_10024133| Dual specificity protein phosphatase 1| dual specificity protein phosphatase hVH1| EGK_17135| erp| H920_04449| HVH1| M91_02132| M959_08318| MAP kinase phosphatase 1| MAP kinase phosphatase-1| MAPK phosphatase 1| MDA_GLEAN10021401| mitogen-activated protein kinase phosphatase 1| mitogen-activated protein kinase phosphatase-1| mitogen-activated protein (MAP) kinase phosphatase-1| mkp-1| MKP1| N300_13042| N301_07412| N302_05359| N303_03055| N305_05795| N306_13913| N307_13796| N310_00448| N311_09353| N312_10789| N320_05173| N321_06071| N324_04116| N325_09015| N328_03530| N329_05885| N330_04695| N331_07490| N332_04167| N333_08530| N334_04329| N335_12505| N336_06642| N339_09561| N340_10333| N341_09365| oxidative stress-inducible protein tyrosine phosphatase| PAL_GLEAN10018894| PANDA_005114| protein-tyrosine phosphatase 3CH134| protein-tyrosine phosphatase CL100| protein-tyrosine phosphatase ERP| protein tyrosine phosphatase, non-receptor type 16| protein-tyrosine phosphatase non-receptor type 16| ptpn10| Ptpn16| serine/threonine specific protein phosphatase| U19515| UY3_09445| XCL100| Y1Q_021595| dusp1

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