Summary of DRD2

The D2 receptor prevents potentiation of glutamate responses in the ventral tegmental area (VTA) neurons. Repeated cocaine treatment causes loss of D2 dopamine receptor functional responses, which is one mechanism of cocaine-induced pleasure/addiction.

It's better to have this gene increased most of the time. Exceptions: psychosis, schizophrenia
0 user want this gene increased, 0 users want it decreased

Protein names

Recommended name:


Short name:


Alternative name(s):

Dopamine D2 receptor

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Top Gene-Substance Interactions

DRD2 Interacts with These Diseases


Substances That Increase DRD2

Substances That Decrease DRD2

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity