Summary of DNMT3A

This gene encodes an enzyme that is involved in DNA methylation. DNA methylation is needed for determining whether the instructions in a particular segment of DNA are carried out or suppressed, regulating reactions involving proteins and fats, and controlling the processing of chemicals. It is associated with cancer (R).

The Function of DNMT3A

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.

Protein names

Recommended name:


Alternative name(s):

DNA methyltransferase HsaIIIA

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Top Gene-Substance Interactions

DNMT3A Interacts with These Diseases

Substances That Increase DNMT3A

Substances That Decrease DNMT3A

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity