Summary of DNMT1

This gene encodes an enzyme that is involved in DNA methylation. DNA methylation is needed for determining whether the instructions in a particular segment of DNA are carried out or suppressed, regulating reactions involving proteins and fats, and controlling the processing of chemicals. It is associated with cancer, deafness, narcolepsy, and other disorders (R).

The Function of DNMT1

Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306).

Protein names

Recommended name:


Short name:


Alternative name(s):

CXXC-type zinc finger protein 9
DNA methyltransferase HsaI
DNA MTase HsaI

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Top Gene-Substance Interactions

DNMT1 Interacts with These Diseases

Substances That Increase DNMT1

Substances That Decrease DNMT1

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity