Summary of DIO1

DIO1 (deiodinase, iodothyronine type I) encodes an enzyme that catalyzes the activation and inactivation of thyroid hormone (R). 

It provides most of the circulating T3, which is essential for growth, metabolism, and differentiation (R). 

The Function of DIO1

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.

Protein names

Recommended name:

Type I iodothyronine deiodinase

Short name:


Alternative name(s):

Type 1 DI
Type-I 5'-deiodinase

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Top Gene-Substance Interactions

DIO1 Interacts with These Diseases


Substances That Increase DIO1

Substances That Decrease DIO1

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity