Summary of CYP3A4

This gene encodes a member of the cytochrome P450 superfamily of enzymes, which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. It also metabolizes some steroids and carcinogens (R). 

The Function of CYP3A4

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide (PubMed:11159812). Catalyzes 4-beta-hydroxylation of cholesterol. May catalyze 25-hydroxylation of cholesterol in vitro (PubMed:21576599).

Protein names

Recommended name:

Cytochrome P450 3A4

Short name:


Alternative name(s):

1,8-cineole 2-exo-monooxygenase
Albendazole monooxygenase
Albendazole sulfoxidase
Cholesterol 25-hydroxylase
Cytochrome P450 3A3
Cytochrome P450 HLp
Cytochrome P450 NF-25
Cytochrome P450-PCN1
Nifedipine oxidase
Quinine 3-monooxygenase
Taurochenodeoxycholate 6-alpha-hydroxylase

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Top Gene-Substance Interactions

CYP3A4 Interacts with These Diseases

Substances That Increase CYP3A4

Substances That Decrease CYP3A4

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity