Summary of CYP2E1

CYP2E1 encodes for an enzyme (Cytochrome P450 2E1) and catalyzes reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids (R). 

The protein is induced by ethanol, the diabetic state, and starvation; because it metabolizes many types of substrates, the gene is related to gluconeogenesis, hepatic cirrhosis, diabetes, and cancer (R). 


The Function of CYP2E1

Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.

Protein names

Recommended name:

Cytochrome P450 2E1

Short name:

CYPIIE1

Alternative name(s):

4-nitrophenol 2-hydroxylase
Cytochrome P450-J

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Top Gene-Substance Interactions

CYP2E1 Interacts with These Diseases

Substances That Increase CYP2E1

Substances That Decrease CYP2E1

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical