Summary of CYP17A1

This gene encodes a protein that is responsible for the formation of steroid hormones. Mutations of this gene are associated with high blood pressure and abnormal sexual development (R). 

The Function of CYP17A1

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.

Protein names

Recommended name:

Steroid 17-alpha-hydroxylase/17,20 lyase

Short name:


Alternative name(s):

17-alpha-hydroxyprogesterone aldolase
Cytochrome P450 17A1
Cytochrome P450-C17
Cytochrome P450c17
Steroid 17-alpha-monooxygenase

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Top Gene-Substance Interactions

CYP17A1 Interacts with These Diseases

Substances That Increase CYP17A1

Substances That Decrease CYP17A1

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity