Summary of CXCL8

C-X-C motif chemokine ligand 8 (CXCL8) encodes a protein that is part of the chemokine family. This protein plays an important role  as a mediator in the inflammatory response. 

Problems associated with CXCL8 include:

  • bronchiolitis (a lung disease) (R)
  • acne (R)
  • cystic fibrosis (R)
  • schizophrenia (R)
  • colon cancer (R)

Function

IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.

Protein names

Recommended name:

Interleukin-8

Short name:

NAF

Alternative name(s):

IL-8
C-X-C motif chemokine 8
Chemokine (C-X-C motif
Emoctakin
Granulocyte chemotactic protein 1
GCP-1
Monocyte-derived neutrophil chemotactic factor
MDNCF
Monocyte-derived neutrophil-activating peptide
MONAP
Neutrophil-activating protein 1
NAP-1
Protein 3-10C
T-cell chemotactic factor
GCP/IL-8 protein IV
IL8/NAP1 form I
(Ala-IL-8
GCP/IL-8 protein II
IL-8(1-77
IL8/NAP1 form II
MDNCF-b
5-77
6-77
(Ser-IL-8
GCP/IL-8 protein I
IL8/NAP1 form III
Lymphocyte-derived neutrophil-activating factor
LYNAP
MDNCF-c
Neutrophil-activating factor
7-77
GCP/IL-8 protein V
IL8/NAP1 form IV
8-77
GCP/IL-8 protein VI
IL8/NAP1 form V
9-77
GCP/IL-8 protein III
IL8/NAP1 form VI

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Top Gene-Substance Interactions

CXCL8 Interacts with These Diseases

Fixes

Substances That Increase CXCL8

Substances That Decrease CXCL8

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity