Summary

C-X-C motif chemokine ligand 8 (CXCL8) encodes a protein that is part of the chemokine family. This protein plays an important role  as a mediator in the inflammatory response. 

Problems associated with CXCL8 include:

  • bronchiolitis (a lung disease) (R)
  • acne (R)
  • cystic fibrosis (R)
  • schizophrenia (R)
  • colon cancer (R)

Function

IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.

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