The Function of CSF2
Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
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Protein names
Recommended name:
Granulocyte-macrophage colony-stimulating factorShort name:
CSFAlternative name(s):
GM-CSFColony-stimulating factor
Molgramostin
Sargramostim
- RS115545556 (CSF2) ??
- RS3091338 (CSF2) ??
- RS657075 (CSF2) ??
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Top Gene-Substance Interactions
CSF2 Interacts with These Diseases
| Disease | Score |
Substances That Increase CSF2
| Substances | Interaction | Organism | Category |
Substances That Decrease CSF2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Protein Tyrosine Kinase Activity
- Ras Guanyl-Nucleotide Exchange Factor Activity
- Granulocyte Macrophage Colony-Stimulating Factor Receptor Binding
Biological Processes:
- Mapk Cascade
- Histamine Secretion
- Embryonic Placenta Development
- Immune Response
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Gene Expression
- Positive Regulation Of Macrophage Derived Foam Cell Differentiation
- Neutrophil Differentiation
- Monocyte Differentiation
- Positive Regulation Of Interleukin-23 Production
- Response To Silicon Dioxide
- Response To Fluid Shear Stress
- Epithelial Fluid Transport
- Macrophage Activation
- Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein
- Myeloid Dendritic Cell Differentiation
- Regulation Of Circadian Sleep/Wake Cycle, Sleep
- Positive Regulation Of Dna Replication
- Negative Regulation Of Cytolysis
- Cellular Response To Lipopolysaccharide
- Positive Regulation Of Podosome Assembly
- Dendritic Cell Differentiation
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand