The Function of CREBBP

Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902).

Protein names

Recommended name:

CREB-binding protein

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Top Gene-Substance Interactions

CREBBP Interacts with These Diseases

Substances That Increase CREBBP

Substances That Decrease CREBBP

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical