Summary of CREB1

This gene encodes a protein that induces transcription of genes in response to the cAMP pathway. Mutations can cause thyroid problems (R). 

The Function of CREB1

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

Protein names

Recommended name:

Cyclic AMP-responsive element-binding protein 1

Short name:


Alternative name(s):

cAMP-responsive element-binding protein 1

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Top Gene-Substance Interactions

CREB1 Interacts with These Diseases

Substances That Increase CREB1

Substances That Decrease CREB1

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity