The Function of COL4A2

Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.

Protein names

Recommended name:

Collagen alpha-2

Short name:

IV

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Top Gene-Substance Interactions

COL4A2 Interacts with These Diseases

Substances That Increase COL4A2

Substances That Decrease COL4A2

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical