Summary of CNR2
This gene encodes the canniboid receptor 2, which is the variety that is responsible for cannabis's anti-inflammatory effect (R). It doesn't have any psychoactive effects.
It's better to have this gene increased most of the time.
The Function of CNR2
May function in inflammatory response, nociceptive transmission and bone homeostasis.
Protein names
Recommended name:
Cannabinoid receptor 2Short name:
CB2Alternative name(s):
CB-2hCB2
CX5
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- RS2229579 (CNR2) ??
- RS2501431 (CNR2) ??
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Top Gene-Substance Interactions
CNR2 Interacts with These Diseases
| Disease | Score |
Substances That Increase CNR2
| Substances | Interaction | Organism | Category |
Substances That Decrease CNR2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression (R):
Tissue specificity:
Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes.
Gene Pathways:
Molecular Function:
Biological Processes:
- G-Protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
- Immune Response
- Inflammatory Response
- Leukocyte Chemotaxis
- Negative Regulation Of Action Potential
- Negative Regulation Of Inflammatory Response
- Negative Regulation Of Mast Cell Activation
- Negative Regulation Of Nitric-Oxide Synthase Activity
- Negative Regulation Of Synaptic Transmission, Gabaergic
- Response To Amphetamine
- Response To Lipopolysaccharide
- Sensory Perception Of Pain
Drug Bank:
- Dronabinol
- Nabilone