Summary of CHRNB2

The CHRNB2 gene encodes a part of a larger protein called a neuronal nicotinic acetylcholine receptor (nAChR). The receptor is needed for chemical signaling between nerve cells. The acetylcholine receptor channels are needed to help control sleep, fatigue, anxiety, attention, pain, and memory (R). 

Mutations can cause epilepsy (R). 


The Function of CHRNB2

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.

Protein names

Recommended name:

Neuronal acetylcholine receptor subunit beta-2

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Top Gene-Substance Interactions

CHRNB2 Interacts with These Diseases

Substances That Increase CHRNB2

Substances That Decrease CHRNB2

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical