Summary of CHAT

ChAT (choline acetyltransferase) produces the protein choline acetyltransferase which produces the neurotransmitter acetylcholine.

Defects in this gene cause abnormal weakness of muscles (myasthenia),  associated with Alzheimer’s, depression, Rett syndrome and schizophrenia.

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The Function of CHAT

Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.

Protein names

Recommended name:

Choline O-acetyltransferase

Alternative name(s):

Choline acetylase

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Top Gene-Substance Interactions

CHAT Interacts with These Diseases

Substances That Increase CHAT

Substances That Decrease CHAT

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity