The Function of CFL1

Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:11812157, PubMed:15580268, PubMed:21834987, PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration.

Protein names

Recommended name:

Cofilin-1

Alternative name(s):

18 kDa phosphoprotein
p18
Cofilin, non-muscle isoform

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Top Gene-Substance Interactions

CFL1 Interacts with These Diseases

Substances That Increase CFL1

Substances That Decrease CFL1

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical