Function

Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:11812157, PubMed:15580268, PubMed:21834987, PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration.

Get a Grip on Your Health. Use SelfDecode to Interpret your Genome Today! GET INSTANT ACCESS

Top Gene-Substance Interactions

Gene Interacts with Diseases

All Ways to Increase Gene

All Ways to Decrease Gene

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical