The Function of CDKN1A

May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.

Protein names

Recommended name:

Cyclin-dependent kinase inhibitor 1

Alternative name(s):

CDK-interacting protein 1
Melanoma differentiation-associated protein 6

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Top Gene-Substance Interactions

CDKN1A Interacts with These Diseases

Substances That Increase CDKN1A

Substances That Decrease CDKN1A

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity