Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.

Protein names

Recommended name:

Cell division control protein 42 homolog

Alternative name(s):

G25K GTP-binding protein

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Top Gene-Substance Interactions

CDC42 Interacts with These Diseases

Substances That Increase CDC42

Substances That Decrease CDC42

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity