Summary of CD36

The protein encoded by this gene is the fourth major glycoprotein of the platelet surface. It transports fatty acids into cells. It functions to promote the storage in of fatty acids in fat cells, utilization in muscles, and help the absorption of dietary fat and cholesterol in the gut. 

CD36 is a receptor for a broad range of molecules, including thrombospondin, fibronectin, collagen or amyloid-beta, oxidized LDL, long-chain fatty acids and bacterial peptides.

When bound to the receptor, these molecules cause inflammatory responses, fatty acid metabolism, taste and dietary fat processing in the intestine.

The receptor is involved in oral fat perception and preferences.  In taste receptor cells, it leads to the activation of the gustatory neurons in the nucleus of the solitary tract (by long-chain fatty acids).


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Protein names

Recommended name:

Platelet glycoprotein 4

Short name:

FAT

Alternative name(s):

Fatty acid translocase
Glycoprotein IIIb
GPIIIB
Leukocyte differentiation antigen CD36
PAS IV
PAS-4
Platelet collagen receptor
Platelet glycoprotein IV
GPIV
Thrombospondin receptor
CD antigen CD36

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Top Gene-Substance Interactions

CD36 Interacts with These Diseases

Substances That Increase CD36

Substances That Decrease CD36

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical