Summary

CCL2 is a molecule that is associated with and increased in many inflammatory conditions.  CCL2 increases risk for many chronic diseases.


Function

Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.

Protein names

Recommended name:

C-C motif chemokine 2

Short name:

HC11

Alternative name(s):

Monocyte chemoattractant protein 1
Monocyte chemotactic and activating factor
MCAF
Monocyte chemotactic protein 1
MCP-1
Monocyte secretory protein JE
Small-inducible cytokine A2

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