The Function of CAV1

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292).

Protein names

Recommended name:

Caveolin-1

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Top Gene-Substance Interactions

CAV1 Interacts with These Diseases

Substances That Increase CAV1

Substances That Decrease CAV1

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical