The Function of CASP8

Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.

Protein names

Recommended name:

Caspase-8

Short name:

CAP4

Alternative name(s):

CASP-8
Apoptotic cysteine protease
Apoptotic protease Mch-5
FADD-homologous ICE/ced-3-like protease
FADD-like ICE
FLICE
ICE-like apoptotic protease 5
MORT1-associated ced-3 homolog
MACH

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Top Gene-Substance Interactions

CASP8 Interacts with These Diseases

Substances That Increase CASP8

Substances That Decrease CASP8

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical