The Function of CASP3

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.

Protein names

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Alternative name(s):

Cysteine protease CPP32
Protein Yama
SREBP cleavage activity 1

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Top Gene-Substance Interactions

CASP3 Interacts with These Diseases

Substances That Increase CASP3

Substances That Decrease CASP3

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity