Recommended name:Cocaine- and amphetamine-regulated transcript protein [Cleaved into: CART
Top Gene-Substance Interactions
Substances That Increase CART
Substances That Decrease CART
Cocaine- and amphetamine-regulated transcript (CART) is a natural stimulant that has roles in pleasure, eating, and stress (R).
CART is a neuropeptide that produces similar behavior to cocaine and amphetamines, including increased physical activity and a positive feeling (R).
CART has been shown to suppress food intake, like cocaine and amphetamines (when injected into the 4th ventricle of rats and in nodose ganglia) (R).
Leptin suppresses food intake and increases energy expenditure at least partially by activating CART neurons (R). Mice without CART genes prefer alcohol less (R), which implicates CART in alcoholism. =