The Function of CAPN10
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.
Protein names
Recommended name:
Calpain-10Short name:
CANP 10Alternative name(s):
Calcium-activated neutral proteinase 10Get a Grip on Your Health. Use SelfDecode to Interpret your Genome Today! GET INSTANT ACCESS
- RS2975766 (CAPN10) ??
- RS3792267 (CAPN10) ??
- RS5030952 (CAPN10) ??
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Top Gene-Substance Interactions
CAPN10 Interacts with These Diseases
| Disease | Score |
Substances That Increase CAPN10
| Substances | Interaction | Organism | Category |
Substances That Decrease CAPN10
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Diabetes mellitus, noninsulin-dependent, 1From UniProt: Diabetes mellitus, non-insulin-dependent, 1 (NIDDM1): A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. [MIM:601283]
From NCBI Gene: Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010] From UniProt: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression (R):
Tissue specificity:
Detected in primary skeletal muscle cells (at protein level). Ubiquitous.
Molecular Function:
Biological Processes:
- Proteolysis
- Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
- Actin Cytoskeleton Reorganization
- Positive Regulation Of Insulin Secretion
- Positive Regulation Of Intracellular Transport
- Cellular Response To Insulin Stimulus
- Positive Regulation Of Glucose Import
- Type B Pancreatic Cell Apoptotic Process
- Positive Regulation Of Type B Pancreatic Cell Apoptotic Process